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Book Details

  • Paperback
  • Bookstore's Wholesale Price: $58.00
  • November 2018
  • ISBN: 978-0-393-67951-9
  • 306 pages
  • Territory Rights: Worldwide

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Case Studies in Cancer


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Richard J. Lee (Author, Harvard Medical School and Massachusetts General), Jeremy S. Abramson (Author, Harvard Medical School and Massachusetts General H), Richard A. Goldsby (Author, Emeritus Amherst College)


A case-based approach to cancer biology

Cancer is the focus of intense clinical and scientific interest. This research increasingly leverages our understanding of molecular biology for the development of targeted therapeutics. Well-selected case studies provide an opportunity to explain specific examples of cancers and their management in the context of engaging, patient-centered cases. This text is a clinical companion for Weinberg’s The Biology of Cancer. However, it includes sufficient background and explanatory detail to be used on its own.


Focuses on the molecular underpinnings of disease

The modern diagnosis and treatment of cancer is intricately tied to the molecular underpinnings of disease. Case Studies in Cancer highlights the broad range of malignancies in which known molecular pathways contribute to tumorigenesis as well as susceptibility or resistance to therapy.  

Cases follow a bench to bedside framework

Every case highlights the relationship between the underlying molecular biology and the disease diagnosis and treatment. A logical, consistent organization of the cases ensures that the translation from “bench to bedside” is always apparent to the reader. 

The perfect companion to Weinberg’s The Biology of Cancer

As a clinical complement for The Biology of Cancer, this text gives exposure to the broad biological and clinical spectrum of cancer. It’s aimed at advanced undergraduates, basic science graduate students, and researchers who may not otherwise get exposure to the diagnosis and treatment of cancer in patient-centered contexts. First and second year medical students will benefit from the “bench to bedside” approach to better understand the biological rationale behind current treatments. 

    1.     Overview of Cancer and Clinical Oncology

    2.     Introduction to Cancer Therapy

    3.     Cytotoxic Chemotherapy

    • a.     Case 3-1: Testicular Cancer
    • b.     Case 3-2: Pancreatic Cancer

    4.     Protein Kinase Inhibition

    • a.     Case 4-1: Chronic Myelogenous Leukemia
    • b.     Case 4-2: Chronic Lymphocytic Leukemia
    • c.     Case 4-3: Lung Cancer
    • d.     Case 4-4: Metastatic Melanoma

    5.     Inhibition of the PI3-Kinase/Akt/mTOR Pathway

    • a.     Case 5-1: Renal Cell Carcinoma
    • b.     Case 5-2: Follicular Lymphoma

    6.     Hormone Therapy

    • a.     Case 6-1: Breast Cancer
    • b.     Case 6-2: Prostate Cancer

    7.     Differentiation Therapy

    • a.     Case 7-1: Acute Promyelocytic Leukemia

    8.     Epigenetic Therapy

    • a.     Case 8-1: Myelodysplastic Syndromes
    • b.     Case 8-2: Cutaneous T-cell Lymphoma

    9.     Targeting Protein Degradation and DNA Repair

    • a.     Case 9-1: Hereditary Breast Cancer
    • b.     Case 9-2: Multiple Myeloma

    10.  Interference with the Tumor Microenvironment

    • a.     Case 10-1: Colorectal Cancer
    • b.     Case 10-2: Multiple Myeloma

    11.  Immunological Strategies: Monoclonal Antibodies

    • a.     Case 11-1: Non-Hodgkin Lymphoma
    • b.     Case 11-2: Hodgkin Lymphoma
    • c.     Case 11-3: Breast Cancer

    12.  Immunological Strategies: Vaccination and Adoptive T-cell Transfer

    • a.     Case 12-1: Cervical Cancer
    • b.     Case 12-2: Acute Lymphoblastic Leukemia
    • c.     Case 12-3: Metastatic Melanoma